Articles & Case Studies

Hot water cascade system for sterilization of liquids

Posted: Thursday 31st July 2014

The hot water cascade system developed by MMM Münchener Medizin Mechanik GmbH enables liquids in closed receptacles made of glass or other temperature-resistant materials(such as ampoules) to be sterilized quickly, reliably and gently. This plays a major role in pharmaceutical/biotechnology production.

GEMÜ valves are used to regulate the filling of the sterilization chamber during the process. This is first filled up to a defined level with deionised sterilization water. This water then circulates through a steam-heated heat exchanger and cascades over the item being sterilized at a continuously rising temperature of up to 121 °C. In the subsequent cooling phase, the sterilization water flows through the now water-cooled heat exchanger and cools the item being sterilized down to a specific temperature.

GEMÜ 554 angle seat globe valve and GEMÜ 490 butterfly valve in equipment room

Pneumatically actuated GEMÜ 554 globe valves control the filling of the sterilization chamber with water and the way in which the heat exchanger is heated by steam and cooled using water. By contrast, GEMÜ 490 butterfly valves are used in the circulation line, as these have significantly more compact installation dimensions yet very high flow rates in comparison with pneumatically operated angle seat globe valves of the same nominal diameter. Furthermore, to meet these stringent requirements, they are fitted with highly resistant TFM TM plastic and FDA-approved silicone as a sealing material.

Background information

GEMÜ is one of the world's leading manufacturers of valves, measurement and control systems. Over the course of 50 years, this globally focused, independent family owned enterprise has established itself in important industrial sectors thanks to its innovative products and customised solutions for process media control. GEMÜ is the world market leader for sterile valve applications in the pharmaceutical industry and biotechnology industries.

Today, the GEMÜ Group employs over 800 employees in Germany and more than 1400 worldwide. Manufacturing is carried out at six manufacturing sites in Germany, Switzerland, China, Brazil, France and the USA. From Germany we coordinate global marketing with 24 subsidiaries and with a large distributor network in 53 markets, the GEMÜ Group is active on all five continents. GEMÜ will continue to establish itself in future markets with its international growth strategy. To achieve this, GEMÜ has opened a new Production and Logistics Centre in 2013.

A broad based modular system and adapted automation components mean that predefined standard products and customised solutions can be combined to make over 400,000 product versions.




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